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Willian says he’s happy at Chelsea amidst transfer rumours

first_imgChelsea’s forward Willian, who has been linked with a move away from the club, on Tuesday said that he’s happy at the London based the club.Real Madrid, FC Barcelona and Manchester United have all been reported to have either made or to be considering offers for the 29-year-old, but in declarations to the Brazilian website Globo Esport, he insisted he didn’t want to leave Chelsea.”I am not moving, I am happy at Chelsea and living in London…I am very happy living in London,” declared the forward.Real Madrid could alter this situation with the European champions reported in Spain to be weighing up a joint offer for Willian and Chelsea’s Belgium international goalkeeper Thibaut Courtois.Meanhwile, defender David Luiz has also dismissed speculation about a potential departure from Chelsea and said he is aiming to win titles under new manager Maurizio Sarri.The 31-year-old, who rejoined Chelsea from Paris St Germain in 2016, will have a chance to re-establish himself at Stamford Bridge following an injury-ridden season, when he made only 10 league appearances under former boss Antonio Conte.His poor domestic run led to his omission from Brazil’s World Cup squad for Russia.”I came back to Chelsea to stay,” Luiz told reporters. “When I took my decision to come back here from Paris it was to win the Premier League and to do something again with Chelsea, so I am very happy here.Luiz has featured in both of Chelsea’s pre-season matches under Sarri, who has started his reign with victories over Inter Milan and Perth Glory.advertisement”I love Sarri’s philosophy,” Luiz said. “We play high, with a lot of possession in a technical way. He’s trying to help us every single day to learn quickly his philosophy.”A new philosophy always takes time. But it also depends on us. If we’re dedicated every day and doing things every single day in training, we’re trying to learn quickly.”Chelsea will face league rivals Arsenal and French top-flight team Olympique Lyonnais in their remaining pre-season fixtures before their Community Shield match against Manchester City on August 5.The London outfit begin their league campaign against Huddersfield Town on August 11.(With IANS and Reuters inputs)last_img read more

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Diana Invests in Newbuild Capesize Bulker

first_imgzoom Diana Shipping Inc. has signed a Memorandum of Agreement to acquire a new-building Capesize dry bulk vessel from an unaffiliated third party seller.The dry bulk carrier, with the capacity of approximately 180,000 dwt, will be built by Qingdao Beihai Shipbuilding Heavy Industry Co., Ltd., China.The vessel, Hull No. BC18.0-50, bought for a purchase price of $58m, is expected to be delivered to the buyer by mid-August 2014.Excluding the newly acquired vessel, as well as two new-building Newcastlemax dry bulk vessels and one new-building Kamsarmax dry bulk vessel expected to be delivered to the company during the second quarter of 2016, Diana’s fleet currently consists of 38 dry bulk vessels.The combined carrying capacity of Diana’s fleet, excluding the four vessels not yet delivered, is approximately 4.21 million dwt, with a weighted average age of 6.83 years.Press Release, June 30th, 2014last_img read more

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APM Terminals Pipavav Welcomes 1st Indian RoRo Service Call

first_imgzoom APM Terminals Pipavav welcomed the IDM Symex car carrier, which arrived with a cargo of 800 Hyundai cars loaded at the Port of Chennai on February 5th, in a pioneering use of coastal transportation of Indian-manufactured automobiles.This is the first domestic consignment since the Indian Ministry of Shipping’s decision to relax cabotage regulations on special vessels.APM Terminals Pipavav, part of the APM Terminals Global Terminal Network, commenced export Roll-on/Roll-off (Ro/Ro) services in August 2015, after NYK Auto Logistics India (NALI) invested in a stock yard and pre delivery inspection facility.“We are proud to be a part of this historic and innovative intra-costal shipment of Indian automobiles, serving India’s growing automotive industry with safe, and environmentally sustainable logistics alternatives,” said APM Terminals Pipavav, Managing Director, Keld Pedersen.The new cars destined for Western India dealerships originated at Hyundai Motor India Limited’s (HMIL) automotive manufacturing facility near Chennai, which is India’s second-largest car manufacturer, and its largest passenger car exporter.India has been projected by auto industry analysts to overtake Japan as the world’s foremost producer of “Entry Level” automobiles within five years, growing its market share from 20% in 2015 to 28% by 2021, as India’s consumer class, along with other emerging market populations targeted by Indian automotive manufacturers, continues to expand. India, with a population of 1.2 billion, is forecast to reach a record 2.2 million new car sales in 2016.last_img read more

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Fire Marshal Urges Caution With Heating Choices

first_img Never use gas camping equipment, barbecues or tent heaters indoors. This equipment is not connected to a chimney, so any carbon monoxide it produces simply goes into the air you breathe, often with deadly results. The province’s fire marshal is asking Nova Scotians to use cautionif using space heaters in their homes. Supplemental heatingdevices continue to be a leading cause of fire and carbon monoxidepoisoning. “Many people use supplemental heating sources during a poweroutage or to help keep home heating costs down, but unsafe use ofthese devices could turn tragic,” says Robert Cormier, NovaScotia’s fire marshal. “These devices carry a much greater risk ofcausing home fires and should be handled with care.” Mr. Cormier says there is an increased risk with space heatersbecause people do not always use them properly. Improper useincludes leaving them too close to mattresses, bedding, clothing,upholstered furniture or other combustible materials, or failingto install, fuel, operate or maintain them properly. A recent study released by the National Fire ProtectionAssociation in the United States, showed 220 people were killed inan estimated 54,900 home heating equipment fires in the U.S. in2001. Five of the most widely used types of portable or fixed spaceheaters include room gas heaters, portable kerosene heaters,portable electric heaters, wood stoves or fireplaces with inserts,and built-in or other fixed electric heaters. The first three havethe highest risk of deaths and injuries, including non-firerelated deaths due to carbon monoxide. Solid-fuelled spaceheaters, such as wood stoves, usually involve the highest risk ofproperty damage from fire. Portable kerosene heaters have thehighest risk of fire death. The U.S. agency says the major causes of home heating firesinclude: –fueling errors involving liquid or gas-fueled heating equipment. Any type of heating equipment can be used safely if you followthese simple rules and recommendations: failure to give space heaters space, by installing or placing them too close to combustible materials or placing combustibles too close to them; Have any heating device installed with proper attention to ventilation. If gas space heaters or fireplaces are used in bedrooms or bathrooms, make sure they are small and that they take their combustion air from outdoors. Canadian fire safety codes prohibit indoor use of propane gas heaters with self-contained fuel supplies. When buying a new space heater, make sure it carries the mark of an independent testing laboratory. Be sure to have fixed space heaters installed by a certified technician according to the manufacturer’s instructions and applicable codes. Have wood and coal stoves, fireplaces, chimneys, chimney connectors and all other solid-fuelled heating equipment inspected by a professional annually, and cleaned as often as the inspections suggest. lack of regular cleaning, leading to creosote buildup in wood- burning devices and associated chimneys and connectors; ENVIRONMENT/LABOUR–Fire Marshal Urges Caution With HeatingChoices basic flaws in construction, design or installation of wood- burning heating equipment; and Allow appropriate clearing from combustibles for all space heaters, usually at least 36 inches (91 centimetres). Follow manufacturer’s instructions when turning a heater on or off. When buying heaters, look for devices with automatic shutoff features. More information on heating devices, is available at the Office ofthe Fire Marshal, 902-424-5721.last_img read more

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High drama in Goa 10 of 15 MLAs split from Congress join

first_imgNEW DELHI/ PANAJI: As it holds onto power by a thread in Karnataka, the Congress has imploded in neighbouring Goa. Ten out of 15 Congress MLAs have split from the party in Goa and have merged with the ruling BJP.”Ten Congress MLAs, along with their Opposition Leader, have merged with the BJP. The strength of the BJP has now risen to 27. They had come for the development of the state and their constituency. They have not put forward any condition, they have joined BJP unconditionally,” Goa chief minister Pramod Sawant said. Also Read – Squadrons which participated in Balakot air strike awarded citations on IAF DayThe Congress is left with only five MLAs in the seaside state where the party had emerged the single largest party in 2017. Since two-thirds of the MLAs have split, they do not have to quit the assembly. The MLAs who broke away are Babu Kavalekar, Babush Monserrate, his wife Jennifer Monserrate, Tony Fernandes, Francis Silveira, Filipe Neri Rodrigues, Clafasio, Wilfred De Sa, Nilkant Halankar and Isidore Fernandes. As they met the Speaker, Chief Minister Pramod Sawant was present. The BJP now has 17 lawmakers in the 40-member assembly.last_img read more

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Could Tesla price cuts mean demand is slowing

first_imgDETROIT — Tesla made about 9,300 more vehicles than it delivered last year, raising concerns among industry analysts that inventory is growing as demand for the company’s electric cars may be starting to wane.If demand falls, they say, the company will enter a new phase of its business. Like other automakers, Tesla will have to either cut production or reduce prices to raise sales. A drop in demand could also curtail the company’s earnings and jeopardize CEO Elon Musk’s promise to post sustained quarterly profits.On Wednesday, Tesla did cut prices, knocking $2,000 of each of its three models. The company said the cuts will help customers deal with the loss of a $7,500 federal tax credit, which was reduced to $3,750 this month for Tesla buyers and will gradually go to zero by the end of 2018.“They have for a long time had more demand than supply,” Gartner analyst Michael Ramsey said. “It’s becoming apparent that that dynamic is changing.”Tesla reported that it produced 254,530 cars and SUVs last year and delivered 245,240.The company’s deliveries for the full year matched Wall Street estimates, but its figures for the fourth quarter didn’t reach expectations. Tesla said it delivered 90,700 vehicles from October through December. Analysts polled by data provider FactSet expected 92,000.Jeff Schuster, a senior vice-president at the forecasting firm LMC Automotive, said demand for Tesla’s lower-priced Model 3 has been artificially high for the past six months as the company overcame production problems at its Fremont, California, factory.“You’ve had these inflated months because of delayed deliveries,” Schuster said. “We’re probably getting to that point where we’re getting to equilibrium and consumers aren’t necessarily waiting for vehicles.”Last year, Tesla reported that about 420,000 buyers had put down $1,000 deposits to join the Model 3 waiting list.LMC predicts that Tesla U.S. sales will rise in 2019 because it’s the first full year on the market for the Model 3. It anticipates sales to then fall by about 10,000 in 2020.Losing the tax credit will hit those who have been holding out for the $35,000 version of the Model 3, Schuster said. At present, Tesla is selling only versions that cost more than $45,000. Under federal law, buyers get the full tax credit until a manufacturer reaches 200,000 in sales since the start of 2010. Tesla hit 200,000 in July but the full credit continued for vehicles delivered by Dec. 31. It was cut in half on Jan. 1 and will go away by the end of the year.“You’ve had your early adopters, those early followers have already come in” to buy, Schuster said. “Now you’re trying to appeal to the mainstream market. I think that will have an impact on overall demand.”At the same time, inventory appears to be swelling. The company parked hundreds of cars at lots and Tesla stores all over the country at the end of last year, which could indicate excess stock. Tesla wouldn’t give inventory numbers but said it has lower stocks than its two biggest competitors, BMW and Mercedes.The Associated Press found one lot on the north side of Chicago where Tesla was storing dozens of vehicles in late December, and Mark Spiegel, a hedge fund manager who bets against Tesla stock, said other lots were full across the country.Tesla said it sometimes stores vehicles on lots as they’re being shipped to company dealerships across the nation. The lot in Chicago has fewer cars on it today, the company said. “Our inventory levels remain the smallest in the automotive industry,” the company said Wednesday.Tesla also says Model 3 sales should grow worldwide as it expands distribution and begins to offer leases. Deliveries in Europe and China will start in February, and a right-hand-drive version is coming later in the year, the company said.In addition, inventory dropped in the fourth quarter as Tesla “delivered a few thousand vehicles more than produced.”Tesla said it had about 3,000 vehicles in transit to customers at year’s end. But even with that number, Schuster said production still exceeded deliveries, which doesn’t fit Tesla’s business model of building cars when they are ordered by customers. Still, even at 9,300, Tesla’s inventory is smaller than other automakers that have to stock dealerships, Schuster said.Tom Krisher, The Associated Presslast_img read more

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Among the Elite Q answers call to send Buckeyes to Elite 8

LOS ANGELES – For at least the first 20 minutes of play, the defects that often doomed Ohio State during a rocky midseason stretch in February seemed to show in glimpses Thursday night at the Staples Center. In their Sweet 16 bout against Arizona, the Buckeyes veered away from the type of play that had gotten them to Los Angeles and leaned on the skill of junior forward Deshaun Thomas, the team’s and Big Ten’s leading scorer. Enter LaQuinton Ross, whose swift flick of the wrist likely made him the most-talked about person in Columbus. Thanks to the sophomore forward’s 3-pointer with 2.1 seconds to play, OSU won the game, 73-70, and will play in the Elite 8 for the second consecutive year. “This is what every player grows up looking at on TV and wants to hit that big shot, wants to win the game and hit the big shot in the NCAA Tournament or the NBA,” Ross said. “It just feels great to be here right now.” It was the second game in a row a late 3-pointer has lifted the Buckeyes. Just last week, junior guard Aaron Craft, OSU’s defensive heart and soul (and a 30 percent 3-point shooter) buried a game-winning shot en route to 18 points, vaulting the Buckeyes past Iowa State in Dayton Sunday. In some ways, Thursday felt like deja vu. But for parts of the first half, even being in the position to win seemed unlikely. While OSU opened the game’s scoring with a basket from Thomas, they seemed anxious and disorganized on both ends of the court. “We started off slow. Guys were being selfish, guys were hugged up on their man, not helping each other out, getting into gaps and tagging,” said Thomas, who finished the night with a game-high 20 points. “I don’t know what it was. It was probably just the heat of the moment. Everybody was just too excited.” Quickly, Arizona coach Sean Miller and the Wildcats took advantage. After falling the victim to an early, furious 10-2 run, the Buckeyes fell behind, 10-4, with 15:46 to play in the period. Behind Arizona senior guard Mark Lyons and his 10 first-half points, the Wildcats shot 50 percent from the field and, in particular, used a lethal 3-point assault to stave off a Buckeye squad that struggled to find momentum. Thomas, the Big Ten’s leading scorer, became a lone pillar for stability as his teammates’ jump shots clanked off the iron and their layups clunked off the backboard. But despite Arizona sinking 63 percent of shots from behind the arc, OSU coach Thad Matta and his crew trotted into halftime down just 38-34, thanks to Thomas and his 16-point outburst in the first period. Having been outscored, outshot and perhaps generally outplayed in the first half against the Wildcats, Thomas said Matta had a singular and simple message. “Coach said do what we do at halftime,” he said, “and that’s what we did.” Craft relayed a similar message. “Our biggest focus was we needed to play better defense,” Craft said. “We gave up 38 points in a half and we haven’t done that too often this year. We got stops and we got easy buckets in transition and that’s where we’re at our best. It really kind of fuels our offense. Layups, dunks, mismatches, scramble situations.” It didn’t take long for OSU to pick up its level of play. The Buckeyes roared out of the gates on a 10-0 run thanks to sophomore forward Sam Thompson, junior guards Lenzelle Smith Jr. and Craft and even sophomore center Amir Williams – who swatted away a shot on one end of the floor before snatching a rebound over two defenders and going up for the jam on the other. Conversely, in that span, Arizona found scoring to be a more troubling endeavor than it was in the first half. In fact, the Wildcats wouldn’t make a basket until freshman forward Brandon Ashley connected on a short jumper a the 14:40 mark of the second. The struggles didn’t end there, either, as Arizona could only muster five points the first nine minutes of the second period and trailed the Buckeyes by as many as 10 after leading all but 33 seconds in the first half. The Wildcats responded, cutting the OSU lead to 60-57 after Lyons buried a trey with 6:33 to play. With 21.8 seconds to play, Lyons tied the game at 70 after making a driving layup despite being fouled, then making the ensuing free throw. It was not enough to overcome Ross – the Buckeyes’ hero – who surged late to score 14 of his 17 total points in the game’s final eight minutes. The Buckeyes have had a revolving door of second scoring options that have played sidekicks to Thomas’ usually steady production. And while his aid came late, Smith said the flavor-of-the-day approach to who will compliment Thomas is a blessing rather than a curse. “That’s such a good thing about this team, you never know who’s gonna step up and be that guy in next game,” he said. “It’s been a knock on us all year. We don’t have offense, you know, we don’t have that second scorer. Well, I mean, I can’t tell at this point, we’re finding guys to make shots.” The Buckeyes (29-7) are set to play No. 9 seed Wichita State Saturday in the Elite 8 at the Staples Center in Los Angeles at 7:05 p.m. read more

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Novichok poisoning Russian suspects in Skripal attack sent coded message saying The

Sources close to the investigation have insisted the British authorities now have the names of those behind the poisonings. The coded dispatch helped cement suspicions that it was the Russian state behind the attempted assassination, before counter terror police using facial recognition technology and CCTV images were able to identify those responsible.It is believed the perpetrators flew back to Russia shortly after carrying out the hit, travelling to London from Salisbury by train.The Telegraph reported in April that key suspects had been identified. following the attack.  Russian agents responsible for the Novichok poisonings in Salisbury sent a coded message to Moscow which included the phrase, “The package has been delivered”, it was claimed last night.A British intelligence listening station based in Cyprus, allegedly picked up the message shortly after former Russian double agent, Sergei Skripal, and his daughter, Yulia, were attacked in March. Yulia and Sergei Skripal But Prime Minister’s deputy official spokesman would not confirm whether the information had been presented to the Russians.She said: “This is an ongoing complex investigation and I can’t comment on the speculation around it. We need to make sure the police have the time and space to carry on with the investigation.” A combination of undated pictures taken from the facebook page of Dawn Sturgess (L) and Charles Rowley (R) Police are now exploring the theory that the assassins discarded a glass bottle containing traces of Novichok in Queen Elizabeth Gardens in the centre of Salisbury, which was discovered three months later by local couple Dawn Sturgess and Charlie Rowley.The investigation became a murder inquiry earlier this month when Ms Sturgess, 44, a mother of three died after she was accidentally poisoned by Novichok.Mr Rowley, 45, is making a slow recovery and has been able to help police piece together the likely movements of the assassins before they fled Salisbury. An inquest into her death was opened by the Wiltshire and Swindon Coroner in Salisbury on Thursday, with her body released to her family for a funeral. It was adjourned until January.”The cause of death will not be given until further tests are completed,” coroner David Ridley said. Maria Zakharova, the Russian foreign ministry spokeswoman, said Moscow has not been officially informed of the identities of the alleged suspects.She said: “No contacts were initiated from the side of British law enforcement or official or diplomatic representatives about this topic today in principle.”All the the information we have is taken from media through leaks or statements. Our London embassy writes requests to confirm or deny this information but doesn’t receive any answers.” Yulia and Sergei SkripalCredit:EAST2WEST NEWS A combination of undated pictures taken from the facebook page of Dawn Sturgess (L) and Charles Rowley (R) Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings. read more

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EA is having a 99cent iOS and Android Easter game sale

first_imgEaster is a nice family holiday. Sure, you’ll see those old aunts who love to pinch your cheek and ask you about when you’re going to meet a nice boy (or girl) and settle down already. If you’d rather revert to your childhood ways and sneak upstairs to your old bedroom to play video games, you’re in luck. It’s as if EA knew this would happen and decided to hold a sale.EA’s second annual Easter sale offers 99-cent games for iOS and Android devices, so you’ll have something to keep you entertained on that long train-, plane-, or bus-ride home. There are almost 30 games on sale.The titles on sale include Monopoly and Tetris for the iPhone for 67 percent off; Dead Space and The Sims 3 for iPhone is 86 percent off, and Scrabble and Dead Space for iPad each has 90 percent off.It appears most Android games are only discounted by 33 percent, but that’s still not a bad deal. There are eight Android games that have been dropped by 50 percent or more.The sale ends after the Easter bunny has returned to its hollow at the end of Sunday night, so don’t hang around and pick up some bargain apps.Check out EA Mobile for the full sale list, via 9to5Maclast_img read more

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Dailymotion sinstalle sur la Freebox Révolution

first_imgDailymotion s’installe sur la Freebox RévolutionUn mois après YouTube, c’est au tour de Dailymotion de débarquer sur le Freebox Révolution. La plate-forme de partage de vidéos fait son arrivée avec la dernière mise à jour du firmware du Freebox Player.Une nouvelle mise à jour du firmware du Freebox Player de la Freebox Révolution a été publiée hier. En plus d’apporter une application Twitter, elle signe l’arrivée de Dailymotion. Un mois après YouTube, le site de partage de vidéo français a lui aussi enfin le droit à son application. “L’intégralité des 22 millions de vidéos du catalogue de Dailymotion est ainsi accessible sur la télé grâce à Free ! ” se réjouit la firme dans un communiqué. À lire aussiOrange va prendre le contrôle de DailymotionL’interface de cette application permet une saisie des mots clefs dans le moteur de recherche via à un clavier virtuel. Les Freenautes disposent en outre des filtres visant à affiner les résultats de leurs requêtes par thématiques, ainsi que différentes options de recherche leur permettant d’accéder aux vidéos les plus populaires, ou les plus regardées. Le service, offert gratuitement, est disponible pour tous les abonnés équipés de la Freebox Révolution, et ce indépendamment de leur éligibilité au service de télévision sur ADSL, précise Dailymotion. Pour y accéder, après avoir installé la mise à jour du Player de la box, il suffit de se rendre dans le menu “Applications”.Le 24 novembre 2011 à 10:30 • Maxime Lambertlast_img read more

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La Nintendo 3DS boostée par les ventes de Noël

first_imgLa Nintendo 3DS boostée par les ventes de Noël Big N doit être rassuré après le mauvais démarrage de sa dernière console portable. La Nintendo 3DS se rattrape plutôt bien pendant les fêtes. Oui, il est certain que Noël a donné un coup de pouce à la 3DS, la nouvelle console portable avec 3D sans lunette. Nintendo commence l’année en annonçant que la barre des 4 millions d’unités vendues vient d’être passée sur le sol américain. Au Japon, cela faisait déjà quelques jours que ce chiffre avait été atteint. Ce succès tardif peut s’expliquer, en partie, par quelques sorties de jeux intéressantes, comme Super Mario 3D et Mario Kart 7, qui ont déjà atteint le million d’exemplaires. Nul doute que le plombier moustachu a motivé les troupes à débourser les 169 dollars que coûte la console (on rappelle qu’à son lancement en janvier 2011, la 3DS en valait 249…).Par la même occasion, Nintendo, en toute fierté, a également annoncé avoir vendu 4,5 millions de Wii et 3,4 millions de DS sur l’année 2011. Plutôt honorable pour des consoles en fin de vie et lorsqu’on sait que la Wii U devrait déjà débarquer l’année prochaine. Période des fêtes finie, reste à savoir si la Nintendo 3DS va continuer à bien se vendre… Le 4 janvier 2012 à 15:45 • Maxime Lambertlast_img read more

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Mucoviscidose symptômes causes traitement où en eston

first_imgMucoviscidose : symptômes, causes, traitement, où en est-on ?Dimanche 29 septembre, se tiendra une nouvelle édition des Virades de l’espoir pour lutter contre la mucoviscidose. L’occasion de faire le point sur cette maladie génétique pour laquelle il n’existe actuellement aucun traitement curatif.Connue depuis plusieurs siècles, la mucoviscidose a été scientifiquement décrite comme maladie vers la fin des années 1930 par une pédiatre américaine, Dorothy Hansine Andersen. Elle est la première à mener une étude poussée pour décrire les caractéristiques de cette pathologie et les symptômes qu’elle engendre chez les malades. Quelques années plus tard, en 1943, le docteur américain Sydney Farber nomme cette maladie “mucoviscidose” créé à partir de “mucus” et “visqueux”.Dès lors, les recherches et observations se multiplient, permettant une meilleure compréhension de la maladie, de ces mécanismes et de ces causes au cours des décennies suivantes. Aujourd’hui, la mucoviscidose est l’une des maladies génétiques les plus fréquentes : elle touche un nouveau-né sur 4.200 en France. Grâce aux recherches, on sait que cette pathologie est due à un dysfonctionnement qui augmente la viscosité du mucus et provoque son accumulation dans les voies respiratoires et le système digestif.Des symptômes variés et plus ou moins sévèresL’atteinte respiratoire est généralement prédominante mais la mucoviscidose peut toucher différents organes, en fonction des individus, de la mutation génétique responsable et d’autres facteurs notamment environnementaux. Aussi, la sévérité de la maladie varie également. Les symptômes cliniques les plus fréquents sont des troubles respiratoires (toux chronique, expectorations, difficultés expiratoires) et des troubles digestifs (constipation, diarrhée, graisses dans les selles).Les manifestations respiratoires sont les causes majeures de morbidité et de mortalité, car la maladie provoque une dégradation progressive de l’état pulmonaire. Suite à l’atteinte, les maladies peuvent présenter des douleurs thoraciques, des pneumopathies récurrentes, de l’asthme voire des pneumothorax qui engagent le pronostic vital. Les lésions dans les poumons s’aggravent aussi progressivement, notamment à cause d’infections bactériennes qui provoquent une inflammation chronique.Le mucus participe normalement à l’élimination des poussières et agents infectieux situés dans les voies respiratoires. Mais celui-ci étant trop visqueux, il est plus difficilement évacué et perd de son pouvoir antibactérien. Ainsi, les micro-organismes ne sont plus correctement éliminés et se mettent à coloniser les voies respiratoires, provoquant des infections chroniques qui participent à la dégradation de l’état pulmonaire. Les manifestations digestives sont elles, les plus précoces et apparaissent dès la période néo-natale.Un risque de malnutritionLa trop grande viscosité du mucus affecte tout l’appareil digestif et empêche les aliments d’être correctement digérés. Au niveau de l’intestin même, le transit peut être ralenti et conduire à de la constipation voire un arrêt des selles. De plus, les enzymes du pancréas qui participent normalement à la digestion peuvent avoir du mal à pénétrer dans l’intestin, ce qui conduit à un syndrome de mal-absorption. Autrement dit, l’impossibilité d’absorber les nutriments nécessaires depuis le bol alimentaire, provoquant des carences voire un retard de croissance dû à la dénutrition.Mais la mucoviscidose peut aussi toucher le foie et la vésicule biliaire, affectant la production de la bile et générant dans certains cas une cirrhose biliaire. Des manifestations génitales peuvent également apparaitre avec une hypofertilité chez les femmes et une stérilité chez les hommes. Parmi les multiples autres complications qui peuvent être observées, figurent aussi du diabète, une augmentation des électrolytes dans la sueur et des atteintes au niveau des articulations ou du coeur. Les atteintes diverses peuvent conduire à la mort si elles ne sont pas prises en charge. Une maladie due à la mutation d’un gène particulierEn vérité, il n’existe pas une mais des mucoviscidoses dans la mesure où plusieurs mutations génétiques en sont à l’origine. Toutes concernent le gène CFTR (pour Cystic fibrosis transmembrane conductance regulator) qui code pour la protéine du même nom dont la fonction est essentielle pour l’organisme. En effet, la molécule CFTR est une sorte de canal ionique qui permet la sortie d’ions chlorure de la cellule. Lorsqu’elle est mutée, la protéine ne remplit plus bien son rôle, ce qui conduit à un déficit en chlore extracellulaire et à la production d’un mucus plus visqueux.Néanmoins, plus de 2.000 mutations différentes du gène CFTR ont été recensées. Certaines conduisent à la production d’une protéine instable quand d’autres altèrent sa fabrication même. C’est pourquoi les symptômes de la maladie sont tellement variables. D’après les recherches, 70% des cas de mucoviscidose sont toutefois causés par une mutation particulière appelée “delta-F508”. Celle-ci conduit à la formation d’une protéine reconnue comme anormale par une autre molécule, la kératine 8 qui se met à la dégrader, ont récemment découvert des chercheurs du CNRS.La mucoviscidose n’est pas contagieuse et n’affecte pas les capacités musculaires ou intellectuelles. Pour être malade, un enfant doit posséder deux gènes CFTR défectueux (un sur chaque chromosome) transmis par ses parents. S’il ne possède qu’une copie du gène muté, il ne sera pas malade mais sera porteur sain, c’est-à-dire qu’il existe un risque qu’il transmette à son tour le gène à ses enfants.Des traitements symptomatiques quotidiens Actuellement, il n’existe aucun traitement pour guérir de la mucoviscidose mais les recherches ont permis la mise en place d’une prise en charge plus adaptée des malades. Aussi, l’espérance de vie de ces derniers a considérablement augmenté au cours des 50 dernières années : elle est passée de 7 ans en 1965 à plus de 45 ans aujourd’hui. De même, la qualité de vie des malades s’est bien améliorée et nombre d’entre eux sont insérés professionnellement et parviennent à fonder une famille.Le traitement actuellement proposé est symptomatique, il sert à soulager les symptômes et à éviter que l’état du malade ne se dégrade. Les soins sont multiples, quotidiens et doivent être accompagnés d’un suivi rigoureux. Au niveau respiratoire, les principaux objectifs sont d’empêcher l’accumulation du mucus et le développement d’infection. Pour cela, on a recours à la kinésithérapie respiratoire qui vise à mobiliser et évacuer les sécrétions bronchiques, à des antibiothérapies pour éliminer les germes et des médicaments mucolytiques pour rendre le mucus moins visqueux.En fonction de la sévérité de la maladie, d’autres traitements peuvent également être utilisés. Dans tous les cas, si elle est efficace, la prise en charge demeure assez contraignante et nécessite au moins 1 à 2 heures par jour, plus en cas de surinfection bactérienne. Une greffe de poumon peut être envisagée si l’atteinte respiratoire est importante. Ajouté à cela, les malades doivent combler les carences dues à la mucoviscidose en prenant à chaque repas des extraits pancréatiques sous forme de gélules ainsi que des suppléments vitaminiques. Il leur faut également surveiller leur alimentation et maintenir un régime fort en calories (100 à 110% des apports journaliers recommandés) pour éviter la dénutrition. Une hydratation régulière est également un facteur à surveiller et une supplémentation en sel peut être nécessaire. Un activité physique ou sportive régulière et adaptée est recommandée pour améliorer l’état respiratoire.Vers un traitement pour guérir la maladie ? La mucoviscidose étant une maladie monogénétique (un seul gène), de nombreuses recherches ont été menées pour tenter de trouver un traitement curatif. Des thérapies géniques ont notamment été testées. Celle-ci vise à remplacer le gène défectueux par un gène sain introduit dans l’organisme par un virus. Néanmoins, les chercheurs se sont exposés à plusieurs obstacles et aucune thérapie génique efficace n’a pu être mise au point jusqu’ici. À lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?Les chercheurs ont ainsi imaginé un autre modèle de traitement qui consiste lui à favoriser le fonctionnement de la protéine CFTR. En effet, des molécules seraient capables d’intervenir dans la maturation de la protéine ou d’empêcher sa dégradation par l’organisme. Ceci permettrait alors à la protéine de se déployer convenablement et de remplir sa fonction, rétablissant le transfert du chlore. Dans une étude publiée ce mois-ci dans la revue EMBO Molecular Medicine, des chercheurs du CNRS ont annoncé avoir découvert deux composés qui pourraient empêcher la dégradation de CFTR en cas de mutation delta-F508.Selon eux, ce traitement pourrait être allié à d’autres molécules visant à accroitre l’activité de la protéine. Une autre stratégie testée par les chercheurs consiste à faire appel à d’autres canaux ioniques qui seraient capables de faire passer les ions chlorure pour pallier la déficience en CFTR. Toutefois, toutes ces recherches sont encore au stade expérimental et il faudra encore davantage d’études avant de pouvoir, peut-être un jour, guérir la mucoviscidose.Le 24 septembre 2013 à 13:38 • Maxime Lambertlast_img read more

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BBC to hold consultation meetings with staff to address gender pay gap

first_imgThe British Broadcasting Corporation (BBC) will hold consultation meetings with staff over the next two months in order to accelerate efforts to close its gender pay gap.Tony Hall, director general at the BBC, confirmed that the media organisation would hold wider consultation meetings with employees to support changes designed to address its 10% gender pay gap in the autumn.The announcement formed part of a letter from Hall in response to an open letter signed by 44 female BBC employees. The open letter requested that the organisation’s gender pay gap be acted upon now, rather than by 2020, which is the deadline the BBC has set for closing the gap and for achieving a 50-50 split between men and women for all lead and presenting roles.The gender pay gap was highlighted in an annex to the BBC’s annual report, BBC pay disclosures July 2017, which details individuals at the BBC who are paid more than £150,000 from license fee revenue in each financial year. The organisation is required to publish this information on an annual basis under the terms of its Royal Charter.The pay disclosures report showed that presenter Chris Evans is the highest paid on-air talent at the BBC, earning between £2,200,000 and £2,249,999, and presenters Claudia Winkleman and Alex Jones are the highest paid women, earning £450,000-£499,999 and £400,000-£449,999, respectively.The open letter to Hall, which has been signed by employees such as sports presenters Clare Balding and Sue Barker, as well as news host Victoria Derbyshire, stated: “Compared to many women and men, we are very well compensated and fortunate. However, this is an age of equality and the BBC is an organisation that prides itself on values.“You have said that you will ‘sort’ the gender pay gap by 2020, but the BBC has known about the pay disparity for years. We all want to go on the record to call upon you to act now.“Beyond the list, there are so many other areas including production, engineering and support services and global, regional and local media where a pay gap has languished for too long. This is an opportunity for those of us with strong and loud voices to use them on behalf of all, and for an organisation that had to be pushed into transparency to do the right thing.”In his response, Hall said: “When I came back to the BBC I said that we needed to move from having only 14% of women on local radio breakfast shows to 50%. We achieved that in two years. I also said we needed to have a 50/50 split on all presenting and lead roles by 2020. You only have to look at our drama and entertainment programmes to see what can be achieved.“But we need to do more to close the gender pay gap. Across the BBC, our provisional figures show that the pay gap is 10% against a national average of over 18%. I have committed the BBC to closing the gap by 2020 and if we can get there earlier then we will.BESbswyBESbswyBESbswyBESbswyBESbswyBESbswyBESbswyBESbswyBESbswyBESbswyBESbswyBESbswy“We are not however making a standing start. Work is already well underway across the organisation to help achieve this. There will be wider consultation meetings over the next two months so we can accelerate further change in the autumn. I would obviously value your contribution and thinking as part of this process.”last_img read more

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Employers look to fill over 1500 positions at South Florida job fair

first_imgMIAMI (WSVN) – Several companies, including a couple of South Florida sports teams, are offering over a thousand positions, Tuesday, in Miami.According to a spokesperson, the Job News USA fair is hosting over 30 companies with more than 1,500 positions to fill. The job fair, taking place at Don Shula’s Hotel at 6842 Main St., includes the Miami Dolphins, Miami Heat and Carnival Cruise Lines, among others.Attendees are asked to pre-register online at www.jobnewsusa.com/southflorida or at the door. According to a news release, parking and admission will be free.Job News USA is also asking attendees to bring resumes tailored for each position.The job fair lasts from 10 a.m. to 2 p.m., Tuesday.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.last_img read more

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The Mother of All Online Magazine Games

first_imgThe mother of all magazine site interactive applications is National Geographic‘s award-winning Your Shot, aningenious combination of user-generated content, photo contest and online games. At Your Shot, visitors can upload photos,compete to have their photos featured in the magazine, and transform photosinto online jigsaw puzzles. According tonews reports, Your Shot alone drives upwards of 14 million page views permonth. The lesson here is (to paraphrase a publisher I had lunchwith last month), “If you act generic, you aregeneric.” Good magazine sites start withthe basic idea (“online games drive traffic”) and then build on it in a waythat fits and reinforces their brands (in Cosmo’s case, sex and boyfriend advice; Nat.Geo., photography). Doing thateffectively can drive outsized results.[IMAGE: Rockstar Games; Grand Theft Auto IV] A typically brief and unscientific survey of magazine sitesreveals a range of approaches to online games, from “blah” to spectacular. Mimicking the success of big game sites like Pogo, many women’s magazine sites include a setof generic, “casual” games—casino games, solitaire, crosswords, wordscrambles, Sudoku, etc. These games areeasily licensed from a number of providers.Ladies Home Journal (9.5 millionmonthly page views) and Reader’s Digest (7million monthly page views) use games as a lure to get visitors to register. Hearst has taken the concept to the next level, partnering with agame developer Arkadium to create gamesinspired by their magazines’ content. Insome cases, the games are not that far removed from their generic versions—Cosmopolitan (35 million monthly pageviews) has Make-up Mah Jonngg and Strip Poker.Other games are a lot more elaborate. Cosmo’s “Boy Toy” is an applicationwhere the player guides a virtual boyfriend to fetch cocktails—and avoid a”skanky ex-girlfriend.”last_img read more

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Are Houstons Sinking Suburbs Suffering Worse Flooding

first_img X To embed this piece of audio in your site, please use this code: 00:00 /03:37 Listencenter_img Source: Journal of the International Society for the Prevention of Mitigation of Natural HazardsTop map shows worse subsidence in blue since the 1990s. Bottom map shows it moving northeast in 2011.What made last month’s flooding, especially in north Harris County, so bad?Simple: a whole lot of rain says Mike Talbott, executive director of the Harris County Flood Control District.“It has a lot to do with this phenomenal rainfall … people don’t want to talk about the rainfall,” Talbott tells News 88.7.But people are talking about how other factors, besides the massive rainfall, may have made things worse. And one those people is a professor of geology at the University of Houston, Shuhab Khan.“It’s making it worse,” says Khan.What Professor Khan believes is making flooding worse in certain neighborhoods is a geological condition Houston and many cities suffer from and have for decades:  subsidence. It’s where many acres of ground sink.Historically in Harris County, subsidence has been worse in areas where over the decades, groundwater and oil and gas have been sucked out from under the ground, causing the land to sink by fractions of an inch a year, in some places by feet over many years.Could it be that today, the ground that homes are built on is sinking in different places than it did decades ago and thus, could this make flooding worse in places where people say, “It never flooded like this before.”When Professor Khan looked at maps showing where last month’s flooding damaged the most homes, those maps looked eerily similar to ones he’d drawn as part of a study two years ago, maps showing where subsidence was happening in Harris County.“Those are the areas that are areas that are subsiding very rapidly. North and northwest. It used to be Jersey Village. (Now) it’s moving northeastwards, north and northeast these days. But it is the same area where the flooding was,” Khan tells News 88.7.Khan says one subsidence zone is drifting northeast towards the Woodlands and seems to be affected by fault lines that traverse the area. Khan is not saying that subsidence alone is why there’s flooding.“Of course there would be flooding. But maybe not huge,” says Khan.At the Flood Control District, Mike Talbott does not agree.“It’s not subsidence,” Talbott told us. “It didn’t have any role in this event, it really was about the rainfall. This was phenomenal rainfall that caused some phenomenal flooding. “Source: Harris County Flood Control DistrictPink shows areas of major flooding April 18thTalbott doesn’t deny subsidence exists. He says the county has been studying it for decades.“Thirty years ago we got ahead of the curve and went ahead and did a major joint study with a bunch of agencies to understand the phenomenon,” says Talbott.Talbott says from those studies they learned that where subsidence is occurring in Houston’s northern suburbs, it’s not like a bowl where if your house is at the bottom you’ll be flooded worse.Instead, he says the sinkage occurs over such a wide area of many square miles that it does not significantly change the depth of the flooding, nor he says will it slow down the flow of creeks in those areas.“Cypress Creek, the subsidence actually is along the creek, the headwaters subsided nearly the same rate as mouth of the stream so the floodplains would move with the land. You wouldn’t have a change in the flow carrying capacity of the system,” Talbott tells News 88.7.Put another way, Talbott is saying that even though the northwest suburbs may have sunk a few feet, they’ll still drain just as fast. He says that’s because those suburbs are still about a hundred feet higher than where the water is headed, which is the Houston Ship Channel near downtown.“The stream just wouldn’t recognize that slight of a change in its slope to really affect the flooding in those areas. It’s a very weak relationship between subsidence and flooding for this region,” Talbott says.It is a complicated geological occurrence that has a long history of debate, a debate renewed when homes flood and people want to know why. 1995 Harris County Subsidence Study Sharelast_img read more

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Get rid of Modi just as he did highvalue notes CM

first_imgRaniganj/Asansol: Coming down heavily on Narendra Modi, Trinamool Congress supremo Mamata Banerjee urged people to scrap him just as he had scrapped high-value notes during demonetisation.”Remember those days when you were forced to face hardships following the note ban. People got up from the bed early morning and found high-value notes had been banned. Modi said it would bring down terrorist activities but in reality, they have gone up. Just as he had scrapped the high-value notes, you scrap him off in the election by casting your votes against him,” she said while addressing two rallies at Raniganj and Asansol on Friday afternoon. Banerjee said: “Modi has ruined the country economically. People have lost jobs. 12,000 farmers have committed suicide but he is unperturbed, he is going from one state to another to narrate lies during the election meetings.” Banerjee added: “During election meetings in other states, Modi is taking the name of Mamata because he knows that in Bengal, BJP will not be able to do anything. They will get a big zero.”last_img read more

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Fernandes denies interest in Indian LCC

first_imgSource = e-Travel Blackboard: N.J AirAsia’s boss has dismissed reports that the Malaysian carrier was looking to purchase an Indian budget carrier.  The carrier’s chief executive Tony Fernandes said speculations were “completely incorrect”. “AirAsia has not submitted a bid for the Indian budget carrier, and has no intention of doing so,” he explained.Meanwhile, UAE carrier, Etihad Airways is said to be close to buying nearly 24 percent in Indian carrier, Jet Airways, Arabian Business reported. Although a Jet Airways spokesperson said the carrier was not able to comment, Etihad chief executive James Hogan said in October this year the carrier was actively looking to expand globally and saw opportunity in India and Asia.last_img read more

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Eightday remand for suspected drug smuggler

first_imgA 35-year-old man was remanded for eight days on Thursday in connection with smuggling some five kilos of cannabis through the post.The suspect was arrested after Greek customs found the Cyprus-bound package at Athens airport containing 5.4 kilos of cannabis.After informing police on the island, the package was sent to Cyprus where the drug squad tracked down the 35-year-old.Limassol district court remanded the suspect, reportedly a special education teacher, an eight-day remand. He denies any involvement and his lawyer did not contest the remand order.He was arrested in Limassol on Wednesday and faces charges including illegally importing, possessing, and possession with intent to supply drugs.You May LikeLuxury Crossover SUV I Search AdsThese SUVs Are The Cream Of The Crop. Search For 2019 Luxury Crossover SUV DealsLuxury Crossover SUV I Search AdsUndoDr. Marty ProPower Plus Supplement3 Dangerous Foods People Feed Their Dogs (Without Realizing It)Dr. Marty ProPower Plus SupplementUndoSecurity SaversWindows Users Advised To Do This TodaySecurity SaversUndo Concern over falling tourism numbersUndoTurkish Cypriot actions in Varosha ‘a clear violation’ of UN resolutions, Nicosia saysUndoOur View: Argaka mukhtar should not act as if he owns the beachUndoby Taboolaby Taboolalast_img read more

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as there is no reasonable suspicion that the applicant committed any crime.samuelson@time.” Abubakar said. Such is the state of affairs in the country, Appearing to be somewhat coordinated, really – dont mess with Sophie Turner on Twitter. Prosecutors may lobby against it because it could taint a potential jury pool." Ted Cruz, first leg against Chelsea at Stamford Bridge on Tuesday, though he stressed that the event was more broadly about approaching social problems with facts—not beliefs—and spoke more of the effect of Trump’s rhetoric than his policies.
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