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Why Exercise Builds Muscle

first_imgYou have stem cells alongside your muscles that provide a ready pool of new muscle cells.In special “niches” alongside muscle cells, muscle progenitor stem cells are at the ready.  When called upon, they can differentiate into new muscle cells.  This is the finding of a German team announcing it in a press release from the Max-Delbrück-Center for Molecular Medicine.A signaling pathway called Notch ensures that the progenitor cells occupy their niche.  How, though, do they stay stem cells?  Notch has a second function: suppressing their differentiation until the called upon.  Consequently, as the headline implies, Notch ensures these stem cells are “at the right place at the right time.”Update  9/27/2012:  Accompanied by a photo of a strong bicep, Science Daily reported that there may be a way to make old muscles feel young again – by replenishing the pool of muscle precursor stem cells to their original state.In other stem cell news:Medical researchers are finding ways to use carbon nanotubes to coax adult stem cells into repairing damaged hearts. (PhysOrg)Scientists at UC San Francisco are figuring out how chromatin modifications during development transform an embryo’s stem cells into heart tissue (Science Daily).Programming of induced pluripotent stem cells (iPSC) is becoming more efficient. (PhysOrg)Scientists are probing the epigenetic signatures of iPSCs to see if they retain signatures of their progenitors (PNAS).  This will undoubtedly become an active area of research in light of the ENCODE project findings.“Stop worrying about human embryonic stem cells – they may not be needed any more,” an article on Gizmag shouted.  Adult stem cells are making them obsolete.Speaking of human cells, the BBC News happily announced improvement to hearing in gerbils with use of human embryonic stem cells.  The rest of the article, though, indicated that the improvement was incomplete (45%), and then stressed that treatment on humans is unlikely.  “While there is excitement at the prospect of using stem cells to restore nerves in the ear this exact technique will not help the vast, vast majority of people with hearing loss,” the article said, adding, “There are also questions around the safety and ethics of stem cell treatments which would need to be addressed.”If there is no need to use human embryonic stem cells, then stop.  Adult stem cells do not have any ethical problems.  Why use ESCs?  A human being is a continuum from zygote to adult.  If it is unthinkable to dissect unborn babies for medical research, then where is the dividing line between growing blastula and newborn?  The last remaining hangouts for ESC research need to cease and desist.  All they need to do can be done with adult stem cells and iPSCs. (Visited 13 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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Growing competitiveness, tackling poverty

first_img5 November 2013 To compete successfully in the global marketplace, South Africa must cultivate an investor-friendly environment while continuing to roll out socio-economic infrastructure, Deputy President Kgalema Motlanthe said on Tuesday. Motlanthe was addressing over 200 high-level representatives of government, business, labour, civil society and academia at the inaugural South African Competitiveness Forum in Midrand, north of Johannesburg on Tuesday. “Beyond the competiveness of our products, we need to prove our worth on a number of socio-economic indicators such as political stability, cultivating an investment-friendly environment, greening the economy, transparency, predictability as well as having good macro-economic policies,” Motlanthe said.‘Platform for identifying risks’ The Deputy President congratulated Brand South Africa for initiating and hosting the forum. “As a first of its kind in South Africa, this forum will give leaders from all spheres a platform for debating our country’s competitiveness, as well as arriving at a common understanding of how to improve the competitiveness of our economy. “By acting in concert, this forum may prove to be an invaluable tool in the identification, management and minimisation of risks in governance, delivery systems, institutional arrangements and other existing procedures.” Motlanthe said South Africans had over the years made good strides in positioning the country as a stable democracy with the necessary institutions and mechanisms for attracting investment. This had resulted in significant investments in South Africa’s automotive, manufacturing, mining, petrochemical and other industries.Challenges of poverty, unemployment However, he said, “we have also fallen short of the development trajectory necessary to place us on par with many of our competitors. These glaring challenges show themselves through high rates of inequality, poverty and unemployment, especially amongst young people, who constitute the majority of our population. “Confronted by the challenges of poverty, inequality and unemployment, we are acutely aware that improvement in the competitiveness of our nation is proportional to strides in these critical areas that define the character of our nation today.” Motlanthe said the government had gone a long way towards improve the social wage through a raft of measures including social grants and investments in education, health care and human settlements. The government’s interventions were aimed at drastically improving training and skills sets, widening access to productive resources, lessening the burden of disease, and generally trying to improve the standards of living for all. Progress ‘predicated on innovation’ Motlanthe said that societal progress in the 21st century was predicated on innovation, adding that South Africa had to maintain its innovative edge in all key sectors of society, particularly the economy. “In turn, innovation assumes that our research and development capacity as a country is of international standards. Research and Development creates conditions in which innovation can keep thriving at every stage. “Logically, this then suggests that our education system be sound and solid, especially in the key areas of science, mathematics and ICT, all of which are the prime drivers of national development.” At the same time, Motlanthe said, education alone would not in the short-term reduce inequalities and unemployment. “We must therefore, in the short to medium term, implement measures that will lead to more rapid growth and creation of jobs. “Using state levers, we need to support growth and development through sound macro-economic policy, strong industrial policy plans and cultivating an investment-friendly environment.” Motlanthe said the South African Competitiveness Forum was an ideal platform for engaging on the challenge of achieving sustainable competitiveness, noting: “Economic growth activities that occur under fair market conditions and that enhance and restore the health of natural and social systems are the essence of sustainable competitiveness. “This forum is in a good position to contribute to a South Africa that continues to become a better place than it was before 1994.” Source: SAnews.gov.zalast_img read more

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Three insider List hacks experienced geocachers use

first_imgThe Premium List feature helps you organize your geocaching life, so you can spend more time looking for caches and enjoying time with your loved ones. To help you make the best of Lists, we are sharing three insider hacks we learned from our experienced geocaching friends.Make every find count.When traveling or when you’re generally short on time, you want to make sure to find only the best geocaches. Here’s how:Use the filtered search on Geocaching.com.Limit Search to…. your preferred location. You can also limit the search by cache type, if you know you won’t have time to solve a Mystery or complete a Wherigo cache. Also, make sure to select ‘Enabled’ under CACHE STATUS to avoid looking for caches that are disabled by their owner.Now add a minimum number of Favorite points. Click ‘Search’.Sort the resulting list by Favorite points and select the first 20 or so caches.Add those to your List.If you know you’ll be in a remote location, make sure to open the Geocaching® App* and download the List for offline use. *Lists automatically sync between web and app.Keep track of your solved Mystery Caches using Lists. Solving Mystery Caches is difficult enough, so you shouldn’t have to deplete brain power keeping track of them. Thankfully there is a great way to stay on top of solved Mysteries using lists.Change the coordinates in the Mystery Cache listing once you solved it. You can do this on Geocaching.com or the Geocaching® app and it will automatically sync.Use the filtered web search to find all of them, by selecting Yes under HAS CORRECTED COORDINATES.Make sure to also chose ‘Not Found’ under Cache Status to only add caches to the list you still have to earn a smiley for.Add the resulting caches to a list and venture out soon to pick the fruit of your brain’s hard labor.Find all caches hidden by your favorite cache owner.If you have geocached for a little while, you will notice that there are geocachers in your area that add just that little bit of extra magic to their geocaches. If you don’t want to miss out on any of their fun cache hides, add them to a List!Use the filtered web search to find geocaches by your favorite cache owner only.Add their name under HIDDEN BY.Make sure to set the CACHE STATUS to Enabled and Not Found and select search.Add the resulting caches to a List and find them all!What List tips are we missing? Share them with us in the comments!Share with your Friends:More SharePrint RelatedFour tips for hiding quality geocachesFebruary 19, 2019In “Geocaching Weekly Newsletter”Everything you always wanted to know about Favorite pointsApril 2, 2019In “News”One map. Endless inspiration.January 22, 2019In “News”last_img read more

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Cinema 4D Video Tutorial: Rock Goo

first_imgLearn how to create a crazy cool ‘rock goo’ effect in Cinema 4D.Creating realistic liquid simulations is a unique challenge for any animator. There are built-in tools inside Cinema 4D which can get you there, but making liquid animation realistic requires skill.Goo or slime, by it’s nature, is difficult to animate. You’ve got to nail the pulling apart and thinning of the material, create realistic dripping, and texture/light the goo so it won’t appear too hard or too soft.It’s not solid and not liquid. It’s a challenge.In the following tutorial created by Nick and Chris from Greyscalegorilla, do a killer job demonstrating how to model, light and texture a realistic ‘liquid goo’ type effect in Cinema 4D:While the end result may seem rather specific, the tutorials covers fundamental 3D animation fundamentals (modeling, texturing, rigging and lighting) that can be applied to any Cinema 4D project. These concepts are covered over 2 hours and broken up into 3 different tutorial videos:Part 1: Modeling the RockPart 2: Modeling & Rigging the GooPart 3: Lighting & TexturingHave any other tips for creating a goo-like substance in Cinema 4D? Share in the comments below.last_img read more

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Sweet Lou helps Clippers trim LeBron-less Lakers

first_imgLou Williams had a season-high 36 points and the Clippers scored 22 consecutive points during the second half of a 118-107 victory over the depleted Lakers on Friday night.Danilo Gallinari added 19 points and 10 rebounds for the Clippers, who held the Lakers without a field goal for more than six minutes while matching the longest unanswered scoring run by any team in the NBA this season.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSUrgent reply from Philippine ‍football chief“We were just a little sluggish,” Williams said. “We were just a step slow. We knew they were on a back-to-back, but for whatever reason, we just weren’t playing our best until we put a good stretch together in the third and then busted the game wide open in the fourth.”The Clippers turned a seven-point deficit into a 15-point lead early in the fourth quarter of their fourth win in five games. Williams torched his former team yet again, scoring 23 points in the second half, yet the game turned with the suffocating defense played by Patrick Beverley, Montrezl Harrell, Avery Bradley and Sindarius Thornwell during that 22-0 run. —AP SEA Games: Biñan football stadium stands out in preparedness, completion SEA Games: Biñan football stadium stands out in preparedness, completion PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Clippers guard Lou Williams puts a shot up against the Lakers’ Josh Hart. APLOS ANGELES—Even while playing without LeBron James on the tail end of a back-to-back set, the Los Angeles Lakers managed to carve out a double-digit lead in the third quarter against the Los Angeles Clippers.That’s when the Clippers’ four toughest defenders clamped down and Sweet Lou went wild to win this basketball-loving city’s first rivalry game of the season.ADVERTISEMENT BREAKING: Corrections officer shot dead in front of Bilibid Is Luis Manzano planning to propose to Jessy Mendiola? Don’t miss out on the latest news and information. Sports Related Videospowered by AdSparcRead Next Private companies step in to help SEA Games hosting LATEST STORIES View comments LOOK: Joyce Pring goes public with engagement to Juancho Triviño MOST READ Pressure? No problem, ‘chill’ Kobe ready to help UP win TS Kammuri to enter PAR possibly a day after SEA Games opening Hotel management clarifies SEAG footballers’ kikiam breakfast issuelast_img read more

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25 days agoBarcelona president Bartomeu to meet with Pique to clear the air

first_imgBarcelona president Bartomeu to meet with Pique to clear the airby Carlos Volcano25 days agoSend to a friendShare the loveBarcelona president Josep Maria Bartomeu is set to meet with defender Gerard Pique to clear the air after the latter’s recent comments.Sport says Pique has questioned the board twice in the last week. He said he did not like the team’s pre-season tours of Japan and the US, claiming “we did more travelling and less training and we’re feeling it.”Then he hinted that the board were planting stories in the media against the players.The objective of the meeting will be to smooth things over and stop Pique’s digs which in Madrid they are using to do more damage to Barcelona. About the authorCarlos VolcanoShare the loveHave your saylast_img read more

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Will not tolerate muscle flexing in state Mamata

first_imgBhatpara/Palta/Rajarhat: Trinamool Congress supremo Mamata Banerjee urged Prime Minister Narendra Modi not to tell lies about Bengal’s development and do a bit of homework before addressing election rallies.Without naming Arjun Singh, BJP nominee for the Barrackpore Lok Sabha seat, Banerjee issued a stern warning and said she would not tolerate any kind of muscle flexing in the area. She addressed a mammoth rally at Bhatpara on Thursday afternoon. Later, she addressed two other meetings at Palta and Rajarhat respectively. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari PujaBanerjee also added that in the past eight years, massive development has taken place in Bengal. Through various schemes, people from all walks of life have benefitted. Over 60 lakh girl students are getting the benefits of “Kanyashree” and around one crore students studying in state-run and aided schools are getting cycles free of cost under the “Sabuj Sathi” project. Around 8 crore people are getting rice at Rs 2 a kilogram under the “Khadya Sathi” scheme. The newly introduced “Swasthya Sathi” project will benefit around 8 crore people and the card will be issued in the name of the senior most woman member of the family as a part of women empowerment. “During Dr BC Roy’s time, development projects had been carried out but after that everything got stalled in Bengal. The Trinamool-led government has carried out massive development in infrastructure,” she said. Also Read – Bengal civic volunteer dies in road mishap on national highway”But there are people who come to Bengal just to defame the state. Modi comes here and spreads lies. He said the government does not allow Durga Puja or Saraswati Puja. More than one lakh Durga Pujas and more than a crore Saraswati Puja are organised in Bengal. He should do a little bit of homework before telling such blatant lies.” Criticising the Prime Minister, she said: “He is so shameless that he does horse trading and says 40 TMC MLAs are in touch with him. Not a single MLA will join him,” she said and alleged: “BJP had banned high-value notes to fill up its own coffers.”last_img read more

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Football Ohio State stays at No 4 in latest AP Poll

The Buckeyes line up to sing “Carmen Ohio” after the game against TCU on Sept. 15. Ohio State won 40-28. Credit: Casey Cascaldo | Photo EditorOhio State stayed as the No. 4 team in the latest AP Poll after defeating TCU 40-28 on Saturday. The Buckeyes failed to earn a first place vote. Ohio State began the season as the No. 5 team in the nation according to the preseason AP Poll, but had failed to earn a first place vote after defeating both Oregon State and Rutgers in the first two weeks of the season. Ohio State did earn a first place vote in the USA Coaches Poll released Sunday, which had the Buckeyes as the No. 4 team in the nation as well. The Buckeyes defeated the Horned Frogs on Saturday, which fell to No. 17 after the loss. Ohio State is one of five teams from the Big Ten represented in the latest AP Poll along with Penn State (No. 10 along with Washington), Wisconsin (No. 18), Michigan (No. 19) and Michigan State (No. 24). The AP Poll: Week 41. Alabama (58)2. Georgia3. Clemson (3)4. Ohio State5. Oklahoma6. LSU7. Stanford8. Notre Dame9. Auburn10. Washington10. Penn State12. West Virginia13. Virginia Tech14. Mississippi State15. Oklahoma State16. UCF17. TCU18. Wisconsin19. Michigan20. Oregon21. Miami22. Texas A&M23. Boston College24. Michigan State25. BYU read more

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Trump names hate groups denouncing Charlottesville violence

first_imgWASHINGTON — Under relentless pressure, President Donald Trump on Monday named and condemned “repugnant” hate groups and declared that “racism is evil” in a far more forceful statement than he’d made earlier after deadly, race-fueled weekend clashes in Charlottesville, Virginia.Trump’s initial failure on Saturday to denounce the groups by name — instead he bemoaned violence on “many sides” — prompted criticism from fellow Republicans as well as Democrats. This time, the president described members of the KKK, neo-Nazis and white supremacists who take part in violence as “criminals and thugs” in a prepared statement he read at the White House.“Racism is evil,” he said, singling out the hate groups as “repugnant to everything that we hold dear as Americans.”“Those who spread violence in the name of bigotry strike at the very core of America,” he said.In his remarks he also called for unity.“We must love each other, show affection for each other and unite together in condemnation of hatred, bigotry and violence. We must rediscover the bonds of love and loyalty that bring us together as Americans,” he said.Trump also, for the first time, mentioned Heather Heyer by name, as he paid tribute to the woman killed when a car plowed into a group of anti-racist counter-protesters in Charlottesville.The president left after his statement without acknowledging reporters’ shouted questions. At an event on trade later in the day, he was asked why it took two days for him to offer an explicit denunciation of the hate groups.last_img read more

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Beckham backs North America World Cup bid

first_imgDavid Beckham has backed North America’s bid to host the 2026 World Cup and is adamant that it would be  “very special”FIFA have received a joint bid from the US, Canada and Mexico to host the 2026 tournament with Morocco being the other.The final decision will be taken next week and Beckham, who used to play for LA Galaxy in the MLS, believes that the football’s big increase in popularity in America over recent years justifies why it should host the World Cup.“A football competition as big as the World Cup deserves to be in great places,” he said, according to Sky Sports.“And if the US, Canada and Mexico get that, it will be very special.“I know the passion that runs through all three of those countries – I played in LA for six years and when we travelled to Canada, I have seen that passion.“And don’t get me started on Mexico! There are not many nations that are as passionate as Mexico.Opinion: De Bruyne is the best crosser since Beckham Tomás Pavel Ibarra Meda – September 13, 2019 We never thought we would see anything remotely like it, but now we can say that De Bruyne is the best crosser since Beckham.Nobody…“I went to a couple of games the last time America hosted the World Cup (1994) and it was incredible.“Now, there are more people who understand the game and get excited about the game.“The infrastructure will be there and, more importantly, the excitement and the passion will be there.“I think a joint bid is important and it is three places where football runs deep.“I have seen how much the game has grown in the last 10 years, people are really getting behind the game“If it does happen I know, as a fan, I will be going to that World Cup.”last_img read more

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