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a month agoWoodward: Solskjaer and Man Utd share philosophy

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Woodward: Solskjaer and Man Utd share philosophyby Paul Vegasa month agoSend to a friendShare the loveManchester United executive vice-chairman Ed Woodward says manager Ole Gunnar Solskjaer has the board’s full support.As the United chief announced record annual revenues of £621.7million today, he insisted the club are on the right track.Woodward stated: “We remain focused on our plan of rebuilding the team and continuing to strengthen our youth system, in line with the philosophy of the club and the manager.”This is reflected in the recent addition of three exciting first team players, key player contract extensions and the talent we have coming through our academy.”Everyone at Manchester United is committed to delivering on our primary objective of winning trophies.” last_img read more

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Biosense Webster treats first patient in US IDE study of HELIOSTAR RF

first_imgThe STELLAR study is an important step forward in expanding treatment options for atrial fibrillation patients in the United States. The burden of atrial fibrillation on quality of life, morbidity and mortality is significant and we are committed to developing innovative and life-enhancing technologies that fill important clinical needs, improve care and reduce this burden.”Uri Yaron, Worldwide President, Biosense Webster, Inc. The HELIOSTAR catheter design has the potential to overcome the limitations of current balloon ablation catheters, result in fewer catheter exchanges and, most importantly, shorter procedure times. HELIOSTAR is an exciting technology and we look forward to seeing the final study results,”Andrea Natale, M.D., F.H.R.S., F.A.C.C., F.E.S.C., cardiac electrophysiologist and Executive Medical Director, Texas Cardiac Arrhythmia Institute at St. David’s Medical Center “This new balloon catheter is unique because it conforms to any pulmonary vein anatomy and allows me to control electrodes individually to deliver tailored energy when ablating around pulmonary veins,” said cardiac electrophysiologist Rodney Horton, M.D., who treated the first patient in the study with Dr. Andrea Natale at the Texas Cardiac Arrhythmia Institute at St. David’s Medical Center. Related StoriesDePuy Synthes launches nerve assessment platform for spine proceduresBiosense Webster enrolls and treats first AF patient in clinical study of new RF balloon catheterJohnson & Johnson announces FDA clearance to expand indication for Acclarent AERA deviceThe HELIOSTAR RF Balloon Ablation Catheter has 10 electrodes, which allows electrophysiologists to deliver different levels of energy depending on the tissue during lesion creation. In addition, the balloon design makes it possible to achieve pulmonary vein isolation with a single application of RF energy. The device is compatible with the Biosense Webster CARTO 3 Mapping System, an advanced imaging technology that enables creation of real-time 3D maps of a patient’s cardiac structures. The use of the CARTO 3 System during an ablation procedure can reduce exposure to radiation from fluoroscopy.It is estimated that 33 million people worldwide are living with AF, or an irregular heartbeat, which can lead to blood clots, stroke, heart failure and other heart-related complications.center_img Dec 4 2018Johnson & Johnson Medical Devices Companies announced today that Biosense Webster, Inc., a worldwide leader in the diagnosis and treatment of heart arrhythmias, has enrolled and treated the first patient in its STELLAR U.S. Investigational Device Exemption (IDE) study. The study will evaluate the safety and effectiveness of HELIOSTAR Multi-electrode Radiofrequency (RF) Balloon Ablation Catheter in treating symptomatic drug refractory recurrent paroxysmal (intermittent) atrial fibrillation (AF). Up to 640 patients will be enrolled in as many as 40 clinical sites worldwide. Source:https://www.biosensewebster.com/last_img read more

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Study highlights the detrimental effect of prescription opioids on labor markets

first_img Source:https://news.utk.edu/2019/01/28/high-rates-of-opioid-prescriptions-may-be-linked-to-poor-labor-force-participation/ Reviewed by James Ives, M.Psych. (Editor)Jan 29 2019Prescription opioids may be negatively affecting labor force participation and unemployment nationwide, according to findings in a new study co-authored by economists at the University of Tennessee, Knoxville, and published in The Journal of Human Resources.The study, which looked at county-level data from across the US, found that a 10 percent increase in opioid prescriptions per capita led to a 0.6 percentage point drop in labor force participation rates and a 0.1 percentage point increase in county unemployment rates.The study, measuring causal effects of opioids on the labor force, is the first of its kind to be published in a peer-reviewed journal, said Matt Harris, assistant professor in UT’s Boyd Center for Business and Economic research and co-author of the study.Related StoriesResearchers use AI to develop early gastric cancer endoscopic diagnosis systemRaman Spectroscopy as a Universal Analytical Technique for Bodily FluidsAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapy”The effects are really large,” said Harris. “Prescription opioids may explain up to half of the decline in labor force participation since 2000.”Harris co-authored the paper, “Prescription Opioids and Labor Market Pains,” with UT’s Larry Kessler, Matt Murray, and Beth Glenn, now a postdoctoral scholar at Tulane University. The researchers were prompted to investigate a link between labor markets and opioid usage after employers began asking why no one was applying for job openings.”We found that opioids have this strong adverse effect on labor force participation but only a marginally significant effect on the unemployment rate, which leads us to believe that opioids are leading individuals to exit the labor force entirely,” said Kessler.Tennessee is among the states with the highest number of heavy opioid-prescribing practitioners. On average, providers in Tennessee write 1.4 opioid prescriptions per person per year. At the average dosage per prescription, this rate is equivalent to prescribing 80 opioid doses to every man, woman, and child in Tennessee each year.The researchers emphasize that addressing the opioid epidemic is going to require considerable funding and an increased focus on treatment therapy. In addition to quelling the adverse health effects of the epidemic, they said, there are considerable economic gains to be attained from addressing the core issue of addiction.”The results suggest that in Tennessee, you could effectively boost income among residents by $800 million per year if you reduce opioid usage 10 percent,” said Harris.Other key findings include:* The detrimental effect of prescription opioids on labor markets holds true for both rural and nonrural counties.* Prescription opioids have the strongest adverse effects in counties with higher labor force participation rates and lower unemployment rates, perhaps suggesting that opioid-related damage has already been done in areas with low labor force participation.last_img read more

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Drugs designed with advanced computing technologies could help tackle hospital superbugs

first_imgSuperbugs are becoming steadily more resistant to antibiotics, causing an ‘antibiotics crisis’ and a serious threat to public health.  In Europe alone 25,000 deaths were linked to antibiotic resistance in 2014. The World Health Organisation estimates that by 2050 this figure will rise to 392,000 and that, worldwide, 10 million people will die from untreatable superbugs.Speaking at the World Economic Forum earlier this year Matt Hancock, the UK Secretary of State for Health, said: Now computational scientists from STFC’s Scientific Computing Department (SCD), STFC Hartree Centre and IBM Research are working together to understand how antibiotic agents operate at the molecular level, and enable the first steps in the efficient design of next generation drugs and treatments. Their findings are published in Physical Review Letters.Using ultra-largescale computer simulations, which were run on the Scafell Pike and IBM Power 8 supercomputers at the Hartree Centre, the team has shown that mechanical stresses on cells can affect the apparent potency of simple antibiotics.   Some antibacterial agents kill microorganisms by attacking their cell membranes, leading to leakage and death of the cell.  But the amount of tension in the cell membrane can make a difference.SCD’s Dr Martyn Winn explains: Jun 6 2019Hospital superbugs such as MRSA or E.coli could soon be under attack from a new generation of drugs designed with the help of advanced computing technologies from STFC and IBM Research. Related StoriesStudy analyzes high capacity of A. baumannii to persist on various surfacesHave cancer, must travel: Patients left in lurch after hospital closesChildren’s Colorado granted IAC’s Cardiovascular Catheterization accreditationThis penetration of the membrane also allows for drugs to infiltrate the cell. Lead author Dr Valeria Losasso from SCD said:  “How antibiotic molecules penetrate and disrupt bacterial membranes is closely related to the permeation of membranes, required to deliver drugs to targets inside the cell. Both require the membrane barrier to be overcome. Our results may therefore have a wider impact on drug delivery, for example how molecules cross cellular barriers before they reach the circulatory system.”The design of drugs which target microbial membranes is seen as a promising strategy, which scientists will continue to investigate.Source:STFCJournal reference:Crain, J. et al. (2019) Modulation of Antimicrobial Peptide Potency in Stressed Lipid Bilayers. Physical Review Letters. doi.org/10.1103/PhysRevLett.122.208103. Antimicrobial resistance is as big a danger to humanity as climate change or warfare.” Imagine the cell as a balloon, where the balloon ‘skin’ is the membrane protecting the bacterium inside. As the bacterium grows the membrane stretches and, like a balloon, it’s easier to poke holes into it. Agents such as antimicrobial peptides, naturally occurring molecules that our bodies produce as a first line of defence against bacteria and viruses, are then more able to launch a successful attack, tearing holes in the membrane and causing the bacterium to leak and effectively bleed to death.” The left-hand figure shows a side view of a normal bacterial membrane at the atomic scale. The right-hand figure shows two changes: 1) the membrane is stretched, making it thinner; 2) the antimicrobial peptide (in green) has punctured the membrane letting in water (blue). The paper investigates how 1) and 2) combine together, to kill the bacterium more effectively. (Credit: SCD/STFC)last_img read more

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Canada panel slams Zuckerberg Sandberg for hearing noshow

first_img Citation: Canada panel slams Zuckerberg, Sandberg for hearing no-show (2019, May 28) retrieved 17 July 2019 from https://phys.org/news/2019-05-canadian-lawmakers-blast-facebook-execs.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 AFP Explore further The panel also adopted a motion to serve the pair with a formal summons to appear before the Canadian parliament’s ethics committee should they ever travel to Canada.”Together, we represent over 402 million citizens,” said Bob Zimmer, chair of Canada’s privacy and ethics committee, which is hosting the meeting.”Mark Zuckerberg’s unwillingness to appear before us and give personal testimony is further evidence that his public comments about working with lawmakers rings hollow.”Although Zuckerberg and Sandberg were no-shows, Facebook’s policy directors Kevin Chan and Neil Potts did appear and faced a grilling.The international committee on big data, privacy and democracy is holding hearings this week in Ottawa to consider ways to prevent social media abuses including privacy breaches, spreading fake news and elections meddling.It met for the first time last year in London, and this round included lawmakers from Argentina, Britain, Canada, Chile, Estonia, Germany, Mexico and Singapore.The panel invited testimony from representatives of Amazon, Apple, Facebook, Microsoft, Mozilla, Twitter and Google, as well as privacy and elections officials, ahead of recommending regulating social media companies in the wake of last year’s Cambridge Analytica scandal.The now-defunct British political consulting firm is alleged to have accessed the personal data of 87 million Facebook users as it worked for US President Donald Trump’s 2016 campaign.Canada’s privacy commissioner Daniel Therrien last month accused Facebook of breaking the law for its role in the worldwide data scandal. He is now taking the company to court to force it to comply with Canada’s privacy law.British lawmaker and panel member Damian Collins blamed the business models of social media companies for such data breaches and the spread of harmful content.”That’s why we cannot rely on companies like Facebook to solve them,” he said.Canadian lawmaker Charlie Angus added: “We are going to move forward with or without Mark Zuckerberg’s input.”Prior to the start of the hearings on Monday, Facebook, Google and Microsoft signed onto a declaration pledging to protect the integrity of Canada’s October federal election—including working to remove sham social media accounts and content.But other tech giants, including Twitter, have not signed the pledge.Critics noted that these undertakings are voluntary and as such are unenforceable.center_img A panel of politicians from Canada and several other nations criticized Facebook’s Mark Zuckerberg and Sheryl Sandberg for ignoring subpoenas Tuesday to appear at a hearing on protecting privacy and democracies online. Facebook CEO Mark Zuckerberg, left, and chief operating officer Sheryl Sandberg failed to appear at a hearing in Canada, angering lawmakers UK, Canada seek to question Facebook’s Zuckerberg on fake newslast_img read more

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Your complete QA guide to Karnataka crisis How it started who stands

first_img India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 16:21 IST Karnataka Chief Minister HD Kumaraswamy (right) and senior Congress leader Siddaramaiah (left). (Photo: PTI)It has been nearly a week since a political pandemonium struck Karnataka and threatened the survival of the HD Kumaraswamy-led Congress-Janata Dal (Secular) government. The battle for Karnataka is being fought on three fronts — in Bengaluru, Mumbai and in the national capital New Delhi.On one hand Chief Minister HD Kumaraswamy claims his house is in order and that his government faces no threat, while on the other, 16 MLAs from his own party and the Congress remain unmoved on their stand – no ghar wapasi (homecoming) to camp Congress-JD(S). To add to Kumaraswamy’s worries, the lone KJKP MLA and one Independent who were supporting his government too have withdrawn their support.WHAT IS THE SITUATION IN KARNATAKA?Simply put, the chaos in Karnataka is about power. Will the ones currently in power retain it or will someone else attain it, is the question that everyone is wondering aloud.The latest news from Karnataka is that 16 MLAs of the ruling parties (13 of Congress and three of JD (S)) have tendered their resignations as MLAs. If their resignations are accepted, the HD Kumaraswamy government’s majority in the state assembly will become questionable and the government will have to win a trust vote – a task which will not be easy in the prevailing circumstances.To make matters worse for the Congress-JD (S) government, KJKP MLA R Shankar, who was a minister, along with an Independent candidate have withdrawn support to the government. Thus the government’s tally in the state assembly will be reduced by 18 if the Speaker accepts all resignations.Hectic parlays are on within the Congress and JD (S) as its leaders try to survive this challenge. Meanwhile, the BJP too has upped the ante as it senses a chance of ousting the present government and form its own.The BJP has been claiming it has nothing to with the mass resignation in Congress and JD (S). It has however been mounting pressure on the Speaker for not accepting the resignations and has also been attacking the Congress after Congress leader DK Shivakumar tore resignation letters of some Congress MLAs inside the Speaker’s office.The Congress and JD (S) have alleged that the present crisis is the BJP’s brainchild.WHY DID THE MATTER REACH SUPREME COURT?On Tuesday, Speaker KR Ramesh examined the 11 resignations that were submitted to his office last Saturday. He confirmed that between Saturday and Tuesday, two more resignations had been submitted, taking the total number to 13.The Speaker said after examining the resignations, he found that eight of them were not in proper order. His office thus returned their resignations and asked the MLAs to send them in prescribed form if they still wanted to resign.For the remaining five MLAs whose resignations were found to be in order, the Speaker asked them to meet him in person to discuss their resignations.Speaker KR Ramesh also wrote to the Governor saying none of these MLAs met him.Unhappy with the Speaker’s decision, the rebel MLAs decided to move the Supreme Court to challenge his decision of rejecting their resignations.WHAT’S HAPPENING IN SUPREME COURT?While the battle for Karnataka is mainly being fought in state capital Bengaluru, the national capital too has become abuzz as the Karanataka crisis has reached the Supreme Court.The rebel JD (S)-Congress MLAs have moved the Supreme Court to challenge Speaker KR Ramesh’s decision where he rejected some resignations. Hearing the pleas, the Supreme Court on Friday said status quo should be maintained in Karnataka till Tuesday when it will hear the case again. The Supreme Court said the Speaker should not take any decision until Tuesday.So, at the moment the Congress-JD (S) government is in power in Karnataka. None of the 16 resignations are effective until Tuesday and the government has a majority.Will this status change on Tuesday? That is something that will be answered only on Tuesday.Meanwhile, on Thursday the Supreme Court asked the rebel MLAs to meet the Speaker and also said the Speaker must decide on the resignations by midnight. In response, the Speaker’s counsel pleaded the court that he would need more time to decide on the matter and that he cannot work at “lightning speed”.The counsel for the rebel MLAs have also demanded that the Speaker must face contempt action as he failed to comply with the Supreme Court’s order to decide on the MLAs’ resignations.BUT WHY IS MUMBAI INVOLVED?Good question. Mumbai ideally has nothing much to do with the power struggle in Karnataka.The only reason why the city has become one of the theatres of action in the battle for Karnataka is that the rebel MLAs are camping in a posh Mumbai hotel.After tendering their resignations on Saturday and meeting Governor Vajubhai Vala, the rebel MLAs reached Mumbai in a chartered flight. Since then they have been in Mumbai, reportedly to ensure that the Congress-JD (S) leaders are unable to “influence” and “intimidate” them.The chartered flight on which these MLAs flew to Mumbai is owned by a company related to BJP’s Rajya Sabha MP Rajeev Chandrasekhar.On Wednesday, Congress’s troubleshooter and state minister DK Shivakumar reached Mumbai in a special flight. He wanted to enter the hotel where the rebel MLAs are staying.Reason for his visit?Well, he said he is in Mumbai just to have coffee with his friends (the rebel MLAs). Not for politics.While Shivakumar said he flew from Bengaluru to Mumbai to have coffee with his “friends”, the visit’s unsaid purpose was clearly to try and convince the MLAs to withdraw their resignations.To placate and lure them, all Congress ministers in Karnataka have resigned so that the MLAs can be adequately accommodated.But this attempt seems to have failed.Apprehending Shivakumar’s visit, the rebel MLAs wrote to Mumbai Police and requested security cover saying they feel “threatened”. The MLAs requested Mumbai Police that DK Shivakumar should be prevented from entering their hotel and meet them. We don’t want to meet him, they said bluntly.When Shivakumar reached the hotel, police were in position to prevent his planned meeting.The hotel too cancelled his reservation citing emergency circumstances.WHAT IS THE GENESIS OF KARNATAKA’S POLITICAL DRAMA?For this, we need to travel back to 2018.In the 2018 Karnataka state assembly election, no party was able to attain majority on its own. The Bharatiya Janata Party (BJP) emerged as the single-largest party with 105 MLAs in the 225-member assembly but fell short of the majority.During the campaign, the BJP, JD (S) and the Congress had fought and campaigned against each other. But following the election results, the Congress and JD (S) stitched a post-poll alliance and formed the government in Karnataka with HD Kumaraswamy of the JD (S) as chief minister.The BJP thus missed the chance to return to power in Karnataka by a whisker. In fact, even in 2018, the government in Karnataka was formed after much political drama and even saw a midnight hearing in the Supreme Court.The drama was such that BJP’s chief ministerial candidate BS Yeddyurappa earned the not-so-good record of becoming the chief minister with the shortest term ever. After the assembly election results were announced, the Governor invited the BJP to form government on the ground that it is the single largest party.Yeddyurappa was sworn in but the Supreme Court made it clear that he can’t appoint any minister, nominate the lone Anglo-Indian nominated MLA nor take any decision before proving his majority on the floor of the state assembly.When the assembly met to vote, Yeddyurappa resigned even before the motion for trust vote was taken up. This was because the BJP had failed to secure the numbers needed to cross the majority mark.Since then, Karnataka has been ruled by a coalition government of the Congress and the Janata Dal (Secular). In the past one year, stability is one aspect that has remained conspicuously absent in the government in Karnataka. Controversies and instability have hampered the functioning of the HD Kumaraswamy government putting it always on the brink of a collapse.As for the opposition Bharatiya Janata Party (BJP), it remains ever vigilant to pounce and grab the slightest opportunity to try form its government.ALSO READ | SC asks Speaker not to take decision on rebels resignation till TuesdayFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byMukesh Rawat Tags :Follow Karnataka crisisFollow Congress JD(S)Follow HD KumaraswamyFollow congress Your complete Q&A guide to Karnataka crisis: How it started, who stands where, what next and moreKarnataka crisis: 16 MLAs from the Congress and JD(S) have resigned and remain unmoved on their stand that they won’t withdraw their resignations. This has threatened survival of the one-year-old HD Kumaraswamy govt.advertisement Nextlast_img read more